Expression and clinical significance of SALL4 expression in gastric carcinoma tissues
10.3969/j.issn.1671-8348.2015.27.004
- VernacularTitle:SALL4基因在胃癌组织中的表达及临床意义
- Author:
Yong GUO
;
Yongliang TANG
;
Juntao YANG
;
Xin ZHANG
;
Lei LIU
- Publication Type:Journal Article
- Keywords:
gastric neaplasms;
immunohistochemistry;
SALL4
- From:
Chongqing Medicine
2015;(27):3756-3758
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and clinical significance of the SALL4 in human gastric carcinoma tissues. Methods The expression of SALL4 in 91 samples of gastric carcinoma and 37 samples of normal gastric tissues was detected by RT-PCR,Western blot and immunohistochemistry,and its relationship with the clinical data were analyzed statistically.Results The positive expression rate of SALL4 in gastric carcinoma(74.7%)was significantly higher than that(18.9%)in normal gastric mucosa tissues(P <0.05).Moreover,with the decreased with the differentiation of gastric carcinoma,the positive expression rate of SALL4 was increased.The expression of SALL4 mRNA and protein in gastric carcinoma tissues were significantly higher than that in normal gastric tissues(P <0.050).The expression levels of SALL4 were relevant to lymph node metastasis(P =0.001),infiltra-tion depth(P =0.029)and the differentiation degree of gastric carcinoma(P =0.050).Conclusion SALL4 was highly expressed in gastric cancer tissues and relevant to lymph node metastasis,infiltration depth and the differentiation degree,which may have play an important role in the development of gastric cancer.
