Changes and clinic correlation of IFN-γ,IL-32 and IL-6 levels in peripheral blood of hepatitis B virus carriers
10.3969/j.issn.1673-4130.2015.18.003
- VernacularTitle:乙型肝炎病毒携带者外周血IF N-γ、IL-32和IL-6的变化及临床相关性
- Author:
Caidong LI
;
Yongwei YANG
;
Huijun LI
;
Pengfei TIAN
;
Bin WU
- Publication Type:Journal Article
- Keywords:
hepatitis B virus carriers;
interferon-γ;
interleukin-32;
interleukin-6
- From:
International Journal of Laboratory Medicine
2015;(18):2622-2624
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore changes of levels of interferon‐γ(IFN‐γ) ,interleukin‐32(IL‐32) and interleukin‐6(IL‐6) in pe‐ripheral blood and the correlation between peripheral IFN‐γ,IL‐32 ,IL‐6 and liver function level and hepatitis B virus(HBV) DNA load in HBV carriers .Methods Sixty HBV carriers ,including 39 cases of chronic HBV carriers and 21 cases of inactive hepatitis B surface antigen(HBsAg) carriers ,and 50 healthy individuals were collected .Serum levels of IFN‐γ,IL‐32 and IL‐6 ,the amount of HBV DNA and liver function were detected ,and clinical correlations were analysed .Results Compared with the control group ,ser‐um levels of IFN‐γ,IL‐32 and IL‐6 of chronic HBV carriers and inactive HBsAg carriers were significantly increased (P<0 .05) . Compared with chronic HBV carriers with low amount of HBV DNA loads and high amount of HBV DNA loads ,chronic HBV car‐riers with medial HBV DNA loads had higher serum levels of IFN‐γ,IL‐32 and IL‐6 ,but no statistically significant differences were observed(P>0 .05) .There was positive correlation between IL‐32 level and ALT level (r=0 .32 ,P<0 .05) ,and negative correla‐tion between IL‐32 level and ALB level(r= -0 .27 ,P<0 .05) .Conclusion IFN‐γ,IL‐32 and IL‐6 may play important roles in chro‐nic HBV infection ,the levels of IFN‐γ,IL‐32 and IL‐6 could be used as important indicators to assess the severity of inflammation in HBV carriers .
