Evaluation of detection of procalcitonin in patients with bloodstream infections
10.3969/j.issn.1673-4130.2015.18.004
- VernacularTitle:降钙素原检测在血流感染患者中的应用评价
- Author:
Wei WANG
;
Jine LEI
;
Xichi JU
- Publication Type:Journal Article
- Keywords:
bloodstream infection;
procalcitonin;
receiver operating characteristic curve
- From:
International Journal of Laboratory Medicine
2015;(18):2625-2627
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of procalcitonin(PCT ) as early predictor of bloodstream infections .Methods Blood culturing and PCT detection were carried out simultaneously in 530 blood specimens collected from the First Affiliated Hospital of Xi′an Jiaotong University from January to December 2014 .All strains were identified by using automatic identification microbial an‐alyzer ,and levels of PCT were analyzed by using automatic enzyme‐linked fluorescent immune system .The diagnostic efficacy of PCT was evaluated by using the receiver operating characteristic(ROC) curve .Results A total of 77 specimens were with negative results of blood culturing ,and a total of 453 specimens were with positive results of culturing .Among those specimens with positive results of blood culturing ,there was 114 strains of gram‐positive bacteria ,306 strains of gram‐negative bacteria ,and 33 strains of fungi .ROC curve analysis showed that the area under the curve of PCT test in all pathogenic bacteria ,gram‐negative bacteria ,gram‐positive bacteria and fungi were 0 .760 ,0 .778 ,0 .741 and 0 .686 ,respectively .In maximum Youden′s indexes ,the cut off values were 0 .453 0 ,0 .683 5 ,0 .457 0 and 0 .399 5 ng/mL respectively ,and 0 .453 0 ng/mL was the threshold in diagnosis of bloodstream infec‐tion .Conclusion PCT is a good indicator for early diagnosing bloodstream infection ,and has better timeliness and higher sensitivity than blood culture .Moreover ,the diagnostic efficacy of PCT for gram‐negative bacteria bloodstream infections was better than that for gram‐positive bacteria and fungi bloodstream infections .
