Preliminary study of the relationship between chronic schizophrenia and oxidative stress
10.3969/j.issn.1673-4130.2015.18.014
- VernacularTitle:慢性精神分裂症与氧化应激关系的初步研究
- Author:
Dan LI
;
Ahong XU
;
Zhenghui YI
;
Zuowei WANG
;
Zhiqiang XUE
;
Ping LIN
- Publication Type:Journal Article
- Keywords:
schizophrenia;
malondialdehyde;
superoxide dismutase;
age
- From:
International Journal of Laboratory Medicine
2015;(18):2650-2651
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore whether the process of oxidative stress exists in schizophrenia through analyzing changes of levels of malondialdehyde(MDA) and superoxide dismutase(SOD) ,and analyse the influence of age on SOD and MDA .Methods Serum levels of MDA and SOD in the schizophrenia group and healthy control group were detected by using enzyme‐linked immu‐nosorbent assay(ELISA) and were statistically analysed by using t test .Results Compared with the healthy control group ,there was an increase in serum level of MDA and a decrease in serum level of SOD in the schizophrenia group ,and had statistically signifi‐cant differences(P<0 .05) .Moreover ,statistically significant differences were found between subjects in the same age group of the two groups(P<0 .05) .Meanwhile ,serum levels of MDA and SOD were respectively compared in the two groups between different age groups ,it was shown that in the schizophrenia group and healthy control group there were no statistically significant differences of serum levels of MDA and SOD between subjects 50 years old and over and subjects younger than 50 years old(P>0 .05) .Conclu‐sion The process of oxidative stress exits in patients with schizophrenia ,and oxidative stress may be involved in the occurrence and progression of schizophrenia .Patients′age may not be significantly correlated with schizophrenia .
