Study on the clinical value of combined detection of HE4,CA199 and CA125 in diagnosis of ovarian cancer and benign ovarian cysts
10.3969/j.issn.1673-4130.2015.18.025
- VernacularTitle:联合检测 HE4、CA125和CA199在卵巢癌和良性卵巢囊肿的应用价值探讨
- Author:
Yanlan OU
;
Liying HUANG
;
Qianfeng HUANG
;
Shaoyi FAN
;
Xiu ZHANG
- Publication Type:Journal Article
- Keywords:
ovarian cancer;
benign ovarian cyst;
human epididymis protein 4;
carbohydrate antigen 125;
carbohydrate antigen 199
- From:
International Journal of Laboratory Medicine
2015;(18):2677-2678
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical value of combined detection of human epididymis protein 4(HE4) ,carbohydrate an‐tigen 199(CA199) and carbohydrate antigen 125(CA125) in diagnosis of ovarian cancer and benign ovarian cysts .Methods The se‐rum levels of HE4 ,CA125 and CA199 were determined by using chemiluminescent immunoassay in 45 cases of patients with ovarian cancer(ovarian cancer group) ,60 cases of patients with benign ovarian cyst(benign disease group) ,and 30 cases of healthy individu‐al(control group) .Results The serum levels of HE4 ,CA199 and CA125 in the ovarian cancer group were higher than those in the ovarian cancer group and control group ,there were statistically significant differences(P<0 .05) .Compared with the control group , the serum level of CA125 in benign disease group was significantly higher(P<0 .05) ,while no statistically significant differences of serum levels of HE4 and CA199 were observed between the two groups(P>0 .05) .The sensitivity of combined detection of the three indicators increased to 82 .2% ,and the specificity remained at 90 .0% .Conclusion Combined detection of HE4 ,CA125 and CA199 might have clinical significance in early diagnosis and identification of ovarian cancer .
