Clinical application value of serum amyloid A protein and C reactive protein in early diagnosis of hand-foot-mouth disease in children
10.3969/j.issn.1673-4130.2015.18.034
- VernacularTitle:血清淀粉样蛋白 A 与C反应蛋白在小儿手足口病早期诊断中的临床应用价值
- Author:
Xueqin ZHAO
;
Qihua LIANG
;
Jialiang HUANG
;
Hongling YANG
- Publication Type:Journal Article
- Keywords:
hand-foot-mouth disease;
C reactive protein;
serum amyloid A protein;
early diagnosis
- From:
International Journal of Laboratory Medicine
2015;(18):2699-2701
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical application value of serum amyloid protein(SAA) and C reactive protein(CRP)in early diagnosis of hand‐foot‐mouth disease(HFMD)in children .Methods The serum/plasma levels of CRP and SAA in 81 children with HFMD(HFMD group)and 125 healthy children(healthy control group)were detected by using dot immunogold filtration as‐say .Data including white blood cell (WBC) count ,levels of CRP and SAA were obtained and analyzed .And diagnostic efficacies of these indicators were evaluated by using receiver operating characteristic (ROC) curve .Results The serum levels of SAA and CRP and WBC count in HFMD group were significantly higher than those in healthy control group ,and all had statistically significant differences(P<0 .05) .The area under the ROC curve(AUC) of SAA(0 .921) was higher than that of CRP(0 .728) ,SAA/CRP ra‐tio(0 .846) and WBC count(0 .721) for diagnosing HFMD ,there were statistically significant differences(P<0 .05) .Compared with CRP ,WBC count and SAA/CRP ratio ,SAA had better diagnostic efficacy .Conclusion As a new biomarker of infections ,SAA can effectively diagnose HFMD early and provide more sensitive reference to clinicians for early diagnosis ,which might be worthy of clinical application widely .
