Expression and clinical significance of annexin A1 in different stages of papillary thyriod carcinoma patients
10.3969/j.issn.1671-8348.2015.25.010
- VernacularTitle:Annexin A1在甲状腺乳头状癌中的表达及临床意义
- Author:
Xuemei ZHONG
;
Min CHEN
;
Shishan DENG
;
Shaoli XIE
- Publication Type:Journal Article
- Keywords:
carcinoma of papilly thyroid neoplasms;
annexin A1;
immunohistochemistry
- From:
Chongqing Medicine
2015;(25):3488-3490
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlations between Annexin A1 protein expression and clinicopathological character-istics in carcinoma of papillary thyroid.Methods The different expressions of annexin A1 in papillary thyroid tissue and para-cari-noma tissue were investigated by immunohistochemistry.Results Among 69 samples tissues of papillary thyriod carcinoma,the positive rate of annexin A1 was higher than that of 69 para-carcinoma tissues(88.41%vs .8.69%),there was a significant difference (P <0.05).Furthermore,the expression of annexin A1 was correlation with the lymph node metastasis and tumor size,which was higher in ≥1 cm diameter of tumor(P <0.05).Conclusion High AnnexinA1 positive expression in papillary thyroid cancer tissues is associated with tumor malignant progression,which might be a valuable predictor and potential target for the diagnosis and treat-ment of papillary thyroid carcinoma.
