Expression of PAR2 in portal vein cancer embolus and hepatocellular carcinoma
10.3969/j.issn.1671-8348.2015.25.033
- VernacularTitle:PAR2在肝细胞癌组织及其门静脉癌栓中的表达
- Author:
Haixia SHAN
;
Chonggui FAN
;
Huaihong ZHANG
- Publication Type:Journal Article
- Keywords:
carcinoma,hepatocellular;
portal vessel tumor thrombosis;
proteinase activated receptor 2
- From:
Chongqing Medicine
2015;(25):3553-3555
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of proteinase active receptor 2(PAR2)protein in hepatocellular carcino-ma(HCC)and portal vessel tumor thrombosis(PVTT)to evaluate its clinical value.Methods Immunofluorescence,RT-PCR and Western blot were used to examine the expression of PAR2 protein in cancer tissue,tumor thrombosis and cancer-adjacent normal tissue from 21 patients with HCC.Results The expression pattern of PAR2 protein was different cancer tissue and cancer-adjacent normal tissue.PAR2 labeling index was significantly higher in cancer tissue and PVTT than cancer-adjacent normal tissue(P <0.05).Although PAR2 labeling index was lower in cancer tissue than in tumor thrombosis,no statistical significance was observed in PAR2 labeling index between them(P >0.05).Conclusion PAR2 is over-expressed in HCC and PVTT.PAR2 expression is re-lated with the development and progression of HCC.
