Multicenter Study on Serum Amyloid A Protein, High-Sensitivity C-Reactive Protein and Procalcitonin in Combining Diagnosis of Infection in Different Population from Guangdong
10.3969/j.issn.1671-7414.2015.04.010
- VernacularTitle:联合检测 SAA，hs-CRP，PCT 和 WBC在广东地区不同年龄人群感染患者诊断价值的多中心分析
- Author:
Qiang LUO
;
Zhenjie LIU
;
Ning XU
;
Weihong ZHANG
;
Yanfen HUANG
;
Dongli MA
;
Peng ZHANG
;
Yan LONG
;
Xuezhen WU
;
Xiongyan XUE
- Publication Type:Journal Article
- Keywords:
serum amyloid A protein;
high-sensitivity C-reactive protein;
procalcitonin;
multicenter study
- From:
Journal of Modern Laboratory Medicine
2015;(4):39-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate combined effect on different population through 2 459 data of SAA,hs-CRP and PCT from 8 three-level hospitals in Guangdong region.Methods Subjects were divided into five groups by ages,and every group had bacterial and virus type.In order to confirm diagnostic effect on infection,methods were performed including in tendency of SAA and hs-CRP,Paired t test between bacterial and virus group,efficiency of 3 indexes in judging infection depending on ROC and parameters,multiple logistic regression,consistency between positive bacterial infection and bacterial culture.Re-sults There were statistically significant differences in SAA and hs-CRP between bacterial and virus in infants and children (P <0.001).SAA had the biggest AUC area 0.824 with sensibility 71.8% and specificity 82.6% in younger group.Corre-sponding,hs-CRP had the biggest area 0.806 with sensibility 84%.There was the accuracy of 78.8% for differential diagno-sis in younger group,while 65.1% in elder group.AUC of SAA was 0.883 for positive bacterial culture with sensibility 71.2% and specificity 90.7%,accuracy of 95.2% for differential diagnosis.Conclusion There was obvious trend of age in SAA and hs-CRP,3 indexes could be used for differential diagnosis alone or combined,especially in younger group.SAA is the best index as a separated index.There is less value at ratio of SAA and hs-CRP.
