Effects of DingKunDan on the endometriosis model rats
- VernacularTitle:定坤丹对子宫内膜异位症模型大鼠的作用
- Author:
Runhua HE
;
Wenyan WANG
;
Bing WEI
- Publication Type:Journal Article
- Keywords:
DingKunDan;
endometriosis;
tumor necrosis factor alpha;
vascular endothelial cell growth factor
- From:
Acta Universitatis Medicinalis Anhui
2015;(11):1693-1695
- CountryChina
- Language:Chinese
-
Abstract:
We built rats model of endometriosis applying autologus endometrial transplants to compare the graft vol-ume of the modeling rats before and after dosing,serum tumor necrosis factor alpha(TNF-α)levels in rats,and the expressions of vascular endothelial cell growth factor(VEGF)in ectopic endometrium.To compare with the control group,the graft volume of DingKunDan group was reduced and the serum TNF-αlevel declined ,and also the ex-pression of VEGF in ectopic endometrium was reduced.Their differences were statistically significant (P <0.05). DingKunDan can inhibit the growth of ectopic endometrium in endometrosis model rats.The mechanism may be re-lated to the decrease of the serum TNF-αlevel and the VEGF expression.
