Roles of UBE2C in breast cancer and its clinical significance
10.3760/cma.j.issn.1673-422X.2015.10.013
- VernacularTitle:泛素耦联酶2C 在乳腺癌中的作用及意义
- Author:
Tao QIN
;
Man LI
- Publication Type:Journal Article
- Keywords:
Cell cycle;
Breast neoplasms;
Ubiquitin-conjugating enzyme 2C
- From:
Journal of International Oncology
2015;(10):766-768
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitin-conjugating enzyme 2C (UBE2C)is involved in cell cycle progression,mitosis regulation and targeted degradation of short-lived proteins.UBE2C is the cancer-related ubiquitin-conjugating enzyme,which is significantly higher in breast cancer tissues compared to the adjacent normal tissue.The abnormal expression of UBE2C participates in the process of occurrence,development and metastasis of breast cancer by the regulation of cell cycle progression,C-erbB-2,cell apoptosis factors and metastasis related genes. It will provide reference for the diagnosis and prognosis of breast cancer.
