Combined oral and intratympanic glucocorticoids treatment for severe to profound sudden sensorineural hearing loss

VernacularTitle:糖皮质激素口服联合鼓室内注射治疗重度和极重度突发性聋
Author: Lu LIU ; Shixun ZHONG
Publication Type:Journal Article
Keywords: Hearing Loss,Sudden; Glucocorticoids; Ear,Middle
From: Chinese Archives of Otolaryngology-Head and Neck Surgery 2015;(9):459-462
CountryChina
Language:Chinese
Abstract: [ABSTRACT]OBJECTIVETo evaluate the efficacy of combined oral and intratympanic glucocorticoids treatment for severe to profound sudden sensorineural hearing loss(SSNHL).METHODSFifty-four patients with severe to profound SSNHL were retrospectively studied. They were treated with oral steroids, vasodilators, anticoagulants. The patients who accepted intratympanic methylprednisolone sodium succinate were included the therapy group, the others were included in the control group. Hearing improvements were analyzed respectively after two weeks.RESULTSHearing in both groups were improved significantly after treatment(P<0.01), but there was no difference in hearing improvements between two groups(P=0.194). The efficacy for severe SSNHL patients in therapy group was equal to those who were in control group (P=0.251), so was the efficacy for profound SSNHL patients in both groups(P=0.380).CONCLUSIONThe combined systemic and intratympanic glucocorticoids treatment was effective for patients with severe to profound SSNHL, but while with no better efficacy than oral glucocorticoid alone.