Effect of brucea javanica oil emulsion combined with radiotherapy for the treatment of patients with esophageal cancer
10.3760/cma.j.issn.1006-9801.2015.09.014
- VernacularTitle:鸦胆子油口服乳液联合放疗治疗食管癌效果观察
- Author:
Zhetao MI
;
Zhifang ZANG
;
Xiufu ZHANG
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Radiotherapy;
Brucea javanica oil emulsion
- From:
Cancer Research and Clinic
2015;(9):627-629
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and untoward effects of brucea javanica oil emulsion combined with radiotherapy in the treatment of patients with esophageal cancer. Methods 50 initial treatment patients with esophageal squamous cell carcinoma were randomly assigned to observation group (25 cases) and control group (25 cases). All patients were treated with three dimensional conformal intensity modulated radiation therapy (3D-IMRT) and the radiation dose was 64 Gy/32 times (95 % PTV). The patients in observation group received the treatment of brucea javanica oil emulsion during radiotherapy. The differences between the two groups were compared in respect of the efficacy, the adverse reactions and the quality of life (QOL). Results The effective rate in observation group was 92%(23/25) and it was 68%(17/25) in control group, there was significant difference between the two groups (χ2 = 4.500, P= 0.034). The incidence of radiation esophagitis at the level of RTOG2 and above in observation group was 20%(5/25) and it was 60%(15/25) in the control group, there was significant difference between the two groups (χ2= 8.333, P=0.004). The improvement rate of QOL in observation group was 68 % (17/25) and it was 40 % (10/25) in control group, there was significant difference between the two groups (χ2 = 3.945, P= 0.047). Conclusion Brucea javanica oil emulsion combined with radiotherapy for the treatment of patients with esophageal cancer can improve the therapeutic effect and QOL,it can also reduce radiation reactions.
