Research progress of mTOR inhibitors in the treatment of breast cancer
10.3760/cma.j.issn.1006-9801.2015.09.020
- VernacularTitle:哺乳动物雷帕霉素靶蛋白抑制剂在乳腺癌治疗中的研究进展
- Author:
Ronghui LI
;
Wu MA
;
Shulian ZHANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
mTOR inhibitors;
Targeted therapy
- From:
Cancer Research and Clinic
2015;(9):646-648
- CountryChina
- Language:Chinese
-
Abstract:
Although the treatment has made great progress in breast cancer, there are still many problems. For example, primary or secondary on chemotherapy drug resistance and the limitation of treatment in triple-negative breast cancer. So, targeted therapy has become a new strategy to improve this situation. Previous studies showed that the occurrence of breast cancer may be related to the activation of PI3K/Akt/mTOR signaling pathways, and mTOR is an index to judge the prognosis. Parts of breast cancers can obtain clinical benefit with mTOR inhibitors, and it might be a potential treatment target in breast cancer.
