Meta-analysis of the association between GSTT1 and the susceptibility to colorectal cancer among ;Chinese population

VernacularTitle:GSTT1基因与中国人群结直肠癌易感性的相关性 Meta 分析
Author: Tianning YANG ; Da ZHAO ; Shoucheng MA ; Quanlin GUAN
Publication Type:Journal Article
Keywords: Colonic neoplasms; Meta-analysis; Glutathione S-transferases T1
From: Journal of International Oncology 2015;(10):743-746
CountryChina
Language:Chinese
Abstract: Objective To assess the association between glutathione S-transferase T1 (GSTT1 )gene and the susceptibility of colorectal cancer among Chinese population.Methods Clinical controlled trials of the association between GSTT1 and the susceptibility of colorectal cancer among Chinese population were searched in PubMed,EMBase,Cochrane Library,China Biology Medicine disc,VIP database,China National Knowledge Infrastructure and Wanfang database.According to the inclusion and exclusion criteria,data extraction and quali-ty assessment were done by two researchers independently.Outcomes were pooled with RevMan 5.1 .Results 326 studies were found and 10 clinical controlled trails including 2 983 cases of colorectal cancer and 4 386 cases of healthy objects were included in this analysis.The results of Meta-analysis showed that the lack of GSTT1 gene is associated with colorectal cancer susceptibility (RR =1 .11 ,95%CI:1 .06-1 .17,Z =4.26,P <0.000 1 ). Conclusion The loss of GSTT1 increase the risk of colorectal cancer among Chinese population.