Mechanism of Raf kinase inhibitor protein down-regulation in cancer
10.3760/cma.j.issn.1673-422X.2015.10.008
- VernacularTitle:肿瘤中 Raf 激酶抑制蛋白下调机制
- Author:
Yun WANG
;
Yuhong LI
- Publication Type:Journal Article
- Keywords:
Phosphatidylethanolamine binding protein;
Neoplasms;
Gene expression regulation
- From:
Journal of International Oncology
2015;(10):750-752
- CountryChina
- Language:Chinese
-
Abstract:
Raf kinase inhibiting protein (RKIP)plays a vital role in various physiological processes and participates in multiple signaling pathways,with a close releationgship with tumor.The mechanism of RKIP down-regulation in neoplasms includes transcriptional regulation,methylation,acetylation,histone modifica-tion,microRNA regulation and NF-κB/Snail/RKIP loop regulation.
