Clinical observation and esophageal dynamical analysis of esomeprazole combined with itopride in the treatment of gastroesophageal relfux disease
10.16066/j.1672-7002.2015.09.004
- VernacularTitle:埃索美拉唑联合伊托必利治疗咽喉反流性疾病及食管动力学分析
- Author:
Fanli LIU
;
Bobei CHEN
;
Xiaoyan CHEN
;
Liyan NI
- Publication Type:Journal Article
- Keywords:
Gastroesophageal Reflux;
THERAPY;
laryngopharyngeal reflux disease;
proton pump inhibitor;
esophageal motility
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2015;(9):445-448
- CountryChina
- Language:Chinese
-
Abstract:
[ABSTRACT]OBJECTIVETo study the changes of symptoms, signs and esophageal dynamics characteristics of laryngopharyngeal reflux diseases(LPRD) before and after treatment with esomeprazole and itopride.METHODS The suspected LPRD patients were took the diagnostic treatment with esomeprazole and itopride. Reflux finding score(RFS), reflux symptoms index(RSI) score and high-resolution esophageal pressure were evaluated before and after treatment. The patients were divided into pure LPRD group and LPRD with GERD group according to gastroesophageal reflux disease(GERD) questionnaire scores.RESULTS There were 38 patients confirmed with LPRD(pure LPRD group:12 cases, LPRD with GERD group:26 cases). The BMI, age, gender ratio had no statistical difference between the two groups(P>0.05). In LPRD group, RSI had significant difference before and after treatment(Z=-3.009,P<0.05), but the RFS had no statistical difference before and after treatment(Z=-0.976, P>0.976). In LPRD with GERD group, the RSI and RFS had significant difference before and after treatment(P<0.05). In LPRD group, the esophageal dynamic change had no significant difference before and after treatment(P>0.05), but in LPRD with GERD group, esophageal dynamic parameters of UESP, LESP, DCI, DL had significant difference before and after treatment(P<0.05).CONCLUSIONIn pure LPRD group, the reflux symptoms improved obviously after treatment, but the signs may need treatment for more time. Esomeprazole combined with itopride can improve the esophageal dynamics in LPRD with GERD group, but can not improve that in pure LPRD group. The results suggested that the LPRD and GERD have different pathogenesis.
