The change of stone composition and its related risk factors in recurrent urolithiasis
10.3760/cma.j.issn.1000-6702.2015.10.007
- VernacularTitle:复发性尿路结石成分变化的发生情况及危险因素分析
- Author:
Wei WANG
;
Fengning MA
;
Ruixian PENG
;
Zhiyuan LIN
;
Guowei SHI
;
Qiang DING
;
Jiayang HE
- Publication Type:Journal Article
- Keywords:
Urolithiasis;
Recurrence;
Stone analysis;
Composition change;
Recurrence interval
- From:
Chinese Journal of Urology
2015;(10):752-756
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the proportion , risk factors and tendency of change of stone composition in recurrent urolithiasis .Methods Eighty-five recurrent urolithiasis patients from 2002 to 2014 were enrolled in this retrospective cohort study .There were 61 male and 24 female patients with a median age of 51 (21-89) years at initial events.Among those patients, 70 had two events, 12 had three events, and 3 had more than 3 events.Compositions of initial and recurrent stones were measured by infrared spectrophotometry.Stone type, recurrence interval and recurrence frequency were studied as potential risk factors for composition change . Chi square test and logistic regression analysis were employed in the statistical analysis.Results Stone composition changed during recurrence in 26 patients ( 30.6%) . Univariate analysis showed the risk ratio of composition change in the patients with recurrence interval of 1-5 years was 0.518 (95%CI, 0.277-0.967, P<0.05) when compared with those of less than 1 year or more than 5 years.Logistic regression analysis showed the odds ratio of recurrence interval of 1-5 years was 0.231 (95%CI, 0.075-0.707, P=0.010).The mutual conversion between calcium oxalate and infection stones was mostly observed when stone composition changed during recurrence .Twenty percent of calcium oxalate stones changed to infection stones and 29.2% of infection stones changed to calcium oxalate .
Conclusions Stone composition changes in about one third patients of recurrent urolithiasis .The mutual conversion between calcium oxalate and infection stones is the most common change .Recurrence interval is an independent risk factor to predict composition change .Repeated stone analysis should be suggested to patients with recurrent interval of less than 1 year or more than 5 years.
