Analysis of prognostic factors in 122 non-small-cell lung cancer patients with brain metastasis
10.3760/cma.j.issn.1006-9801.2015.09.010
- VernacularTitle:非小细胞肺癌脑转移122例预后因素分析
- Author:
Peng JIANG
;
Yang WU
;
Yong XIN
;
Yuanhu YAO
;
Longzhen ZHANG
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Brain metastasis;
Prognosis
- From:
Cancer Research and Clinic
2015;(9):612-616
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the prognostic factors of non-small-cell lung cancer (NSCLC) patients with brain metastasis. Methods 122 NSCLC patients with brain metastasis from Jan 2007 to Dec 2012 were incorporated, and followed with death as the end. The influence factors of prognosis were retrospective analyzed. Kaplan-Meier method was used for survival analysis, the Log-rank test for single factor analysis,and Cox regression model for multiple factors analysis. Results The single-factor and multi-factor analysis showed that the influence factors of prognosis were age, pathological type, number of intracranial metastasis, presence of extracranial metastasis, treatment, Karnofsky score, the original site control situation (P<0.05). Gender, the size of the original site had no influence for prognosis (P>0.05). The average survival times of patients with palliative symptomatic treatment, simple whole brain radiotherapy, whole brain radiotherapy local lesion plus the amount of radiation, whole brain radiotherapy local lesion plus the amount of radiation combined with chemotherapy were (2.14 ±0.19) months, (7.28 ±0.60) months, (16.90 ±1.35) months, (17.7±1.12) months, 1 year survival rates were 0, 8.5%, 71.0%, 93.3%. Survival analysis showed that there was statistical significance among the four groups (P= 0.000). Conclusion The age, pathological type, number of intracranial metastasis, presence of extracranial metastasis, treatment, Karnofsky score, the original site control situation are the prognosis factors in NSCLC patients with brain metastasis, therefore the treatment of these patients should be comprehensively analyzed.
