Research progress of pathogenesis of phenotype shift of gastric intestinal metaplasia
10.3760/cma.j.issn.1006-9801.2015.09.018
- VernacularTitle:胃黏膜肠化生表型转变机制的研究进展
- Author:
Haijing NIU
;
Bingzhong SU
- Publication Type:Journal Article
- Keywords:
Gastric intestinal metaplasia;
Phenotype shift;
Pathogenesis
- From:
Cancer Research and Clinic
2015;(9):640-642
- CountryChina
- Language:Chinese
-
Abstract:
Gastric intestinal metaplasia (IM), a common clinical pathological diagnosis, is a premalignant condition of intestinal type gastric cancer. The pathogenesis is still unclear, which links with helicobacter pylori (Hp) infection, bile reflux, nitrite intake, vitamin deficiency and so on. In recent studies, the relevant genes involved with transdifferentiation of gastric epithelium to intestinal epithelium are CDX2, SOX2, PDX1, OCT1, SHH, Runx3, Tff, and so on. Overall, the phenotype shift of gastric intestinal metaplasia is a complex and long process, current treatments targeted to the cause of IM such as Hp infection, bile reflux only can prevent its development, but fail to reverse the clinical process, so further clarification to the pathogenesis is still needed to guide the clinical treatment.
