Expression and Relation of TERT and AP-1 in Laryngeal Carcinoma

VernacularTitle:端粒酶逆转录酶与转录激活蛋白－1在喉癌组织中的表达及相关性研究
Author: Yaping WANG ; Chen CHEN ; Bokui XIAO ; Lingxiang LI
Publication Type:Journal Article
Keywords: Laryngeal carcinoma; Telomerase reverse transcriptase(TERT); Acticator protein1(AP-1)
From: Journal of Audiology and Speech Pathology 2015;(5):493-496
CountryChina
Language:Chinese
Abstract: Objective To investigate telomerase reverse transcriptase (TERT ) and acticator protein 1(AP -1) expression and it's corroloation in laryngeal carcinoma tissue .Methods 24 human laryngeal carcinoma tissue were analised by RT -PCR and quantum -dot based immunofluorescence assay for the expression of TERT and AP -1 . Results The expression of TERT mRNA and the expression of c -Fos ,c-Jun in laryngeal carcinoma were postive‐ly related .Correlation coefficient was 0 .574 and 0 .809 ,respectivly(P<0 .01) .Conclusion TERT and AP -1 were expressed at high levels and positively correlated in human laryngeal carcinoma .