The Anatomic Differences of Endolymphatic Sac among Common Laboratory Rodents

VernacularTitle:豚鼠、大鼠和小鼠内淋巴囊组织学的差异
Author: Daxiong DING ; Fengbo YANG ; Ping LV ; Guowei HUANG ; Xiaodong WANG ; Chen LIU ; Yue ZHANG ; Shiming YANG ; Ning YU
Publication Type:Journal Article
Keywords: Rodents; Cochlea; Endolymphatic sac
From: Journal of Audiology and Speech Pathology 2015;(5):497-499
CountryChina
Language:Chinese
Abstract: Objective To compare the differences of laboratory rodents endolymphatic sac (ES) in histology , and to provide an anatomic basis for the clinical research of ES -related diseases .Methods The temporal bones of guinea pigs ,SD rats and KM mice were fixed by heart perfusion ,sectioned by paraffin at the horizontal position and stained by hematoxylin -eosin (HE) .Results All 3 rodents ES contained sac ,epithelium ,sub-mucosal tissue and saccal stroma .The cells were bulky ,stained deep and protruded into the cavity to form a large number of nipples and wrinkles in the middle ES epithelial of guinea pigs .But the nipples or wrinkles was rarely observed in the middle ES epithelial in rat and mouse .Conclusion The histology of ES has significant difference among guinea pig ,mouse and rat .While the difference betweeen mouse and rat is not obvious .