Effects of Tian-Shu Dripping Pills on Cerebral Blood Circulation among Anesthetized Canine
10.11842/wst.2015.09.007
- VernacularTitle:天舒滴丸对麻醉犬颅内循环的影响＊
- Author:
Qingqing HENG
;
Chaohui TANG
;
Liang CAO
;
Na LI
;
Gang DING
;
Wei XIAO
- Publication Type:Journal Article
- Keywords:
Tian-Shu Dripping Pills;
cerebral blood flow;
cerebral vascular resistance
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2015;(9):1790-1794
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to observe the effects ofTian-ShuDripping Pills (TSDP) on cerebral hemodynamics among anesthetized dogs, in order to demonstrate its clinical treatment functional correlation on angioneurotic headache. A total of 25 hybrid dogs were randomly divided into the normal saline (NS) group, TS capsule (positive control: 0.4 g·kg-1 crude medicine) group, low-dose TSDP (0.2 g·kg-1 crude medicine) group, middle-dose TSDP (0.4 g·kg-1 crude medicine) group, and high-dose TSDP (0.8 g·kg-1 crude medicine) group.Intraduodenal administration was given once under anesthesia. Changes of mean arterial blood pressure, blood flow of vertebral artery and internal carotid artery blood flow were detected and the cerebral blood flow and cerebral vascular resistance were calculated. The results showed that TSDP of low-dose, middle-dose and high-dose group can significantly reduce the cerebral vascular resistance and increase the cerebral blood flow within 180 min after medication. It was concluded that TSDP can improve the cerebral blood circulation of anesthetized dogs. Its mechanism may be through the reduction on cerebral vascular resistance and increasing of cerebral blood flow.
