Construction of rat models of failed back surgery syndrome and the possible mechanisms of Shenshu magnetic stimulation therapy
10.3969/j.issn.2095-4344.2015.40.004
- VernacularTitle:构建腰椎手术失败综合征大鼠模型及肾俞磁刺激治疗的可能机制
- Author:
Feng WU
;
Xuanhuang CHEN
;
Manwei HUANG
;
Haibin LIN
;
Jinqing ZHENG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2015;(40):6413-6417
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:The important reason for failed back surgery syndrome is the postoperative epidural scar adhesions, therefore, exploring the methods of preventing postoperative lumbar epidural scar adhesions has always been a hot research in spine surgery field. OBJECTIVE:To investigate the effect of Shenshu point magnetic stimulation therapy on epidural scar adhesions in rat models of failed back surgery syndrome. METHODS:Sixty Sprague-Dawley rat models of failed back surgery syndrome were successfuly established using the method of laminectomy, and then divided into Shenshu magnetic therapy group and blank control group. Beginning from 1 week after modeling, rats in the Shenshu magnetic therapy group were subjected to bilateral Shenshu magnetic stimulation for 6 weeks, 5 days of treatment per week. Rats in the blank control group were not given any intervention. At 13 weeks after modeling, rats were harvested and the area ratio of epidural scars, range of adhesions and formation of colagen fibers were observed under light microscope. Fibroblasts were counted. Hydroxyproline content and transforming growth factor β1 expression in scar tissue were compared between these two groups.
