Clinical evaluation on Yishen-Bushui-Tongluo decoction in the treatment of multiple sclerosis
10.3760/cma.j.issn.1673-4246.2015.09.006
- VernacularTitle:益肾补髓通络汤联合强的松治疗多发性硬化的临床研究
- Author:
Jing LYU
- Publication Type:Journal Article
- Keywords:
Multiple sclerosis;
Bushen-Yisui-Tongluo decoction;
Adrenocorticotropic hormone;
Integrated Chinese traditional and Western medicine therapy
- From:
International Journal of Traditional Chinese Medicine
2015;37(9):788-791
- CountryChina
- Language:Chinese
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Abstract:
Objective To evaluate clinical efficacy of Yishen-Bushui-Tongluo decoction in the treatment of multiple sclerosis (multiplesclerosis, MS).Methods 60 patients met the inclusion criteria of MS were recruited into a compound group and a control group, with 30 patients in each. The control group was treated with conventional western medicine, while the compound group was treated withYishen-Bushui-Tongluo decoction on the basis of the control group. Both groups were treated for continuous 3 months, the clinical efficacy, symptoms, signs, expanded disability scale (expanded disability status scale, EDSS) scores, as well as adverse reactions and hormone-year recurrence rate were compared between the two groups.Results After the treatment, the total effective rate was 93.3% (28/30) in the compound group and 73.3% in the control group (22/30), showing statistically difference (χ2=4.320,P=0.038). After treatment, the clinical symptom score (5.1 ± 2.7vs. 7.0 ± 3.1,t=2.532), neurological signs score (5.1 ± 1.6vs. 6.3 ± 1.7, t=2.815), EDSS score (3.4 ± 1.5 vs.4.8 ± 1.5,t=3.615) in the compound group were significantly lower than the control group (P<0.01 or P<0.05); the follow-up period of 1 year showed the recurrence times in the compound group was lesser than the control group (0.31 ± 0.17vs.0.89 ± 0.36;t=7.980,P=0.000).ConclusionsYishen-Bushui-Tongluo decoction combining conventional western therapy can significantly improve the clinical symptoms of MS patients, relieve nervous system damage mitigation, reduce relapse frequency, and reduce the adverse effects of hormones.
