eNOS gene G10T polymorphism in 1290 children with sporadic congenital heart disease

VernacularTitle:1290例散发型先天性心脏病患儿内皮型一氧化氮合酶基因G10T多态性
Author: Kai ZHOU ; Yuming QIN ; Xuming MO
Publication Type:Journal Article
Keywords: sporadic congenital heart disease; endothelial nitric oxide synthase; gene polymorphism; child
From: Journal of Clinical Pediatrics 2015;(9):807-809
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the association between endothelial NO synthase (eNOS) gene G10T polymorphism and the susceptibility of sporadic congenital heart disease (CHD).MethodsThe genotype oneNOS G10T locus was detected and compared in 1323 children with sporadic CHD and 1323 non-CHD children.ResultsCompared with the CC genotype, the AA genotype signiifcantly increased the risk of CHD (adjustedOR=1.42, 95%CI=1.01-2.04). Compared with the CC/AC geno-type, the AA genotype signiifcantly increased the risk of CHD (adjustedOR=1.39, 95%CI=1.08-1.92). Based on stratiifed analy-sis, the AA genotype was associated with the susceptibility of perimembranous ventricular septal defects (adjustedOR=1.56, 95%CI=1.17-2.47).ConclusionsIn Chinese population, theeNOS G10T polymorphism may increase the susceptibility of sporadic CHD.