Research progress of activating transcription factor 4 in glucose and lipid metabolism
10.3969/j.issn.1006-6187.2015.09.021
- VernacularTitle:激活转录因子4与糖脂代谢相关性的研究进展
- Author:
Pu ZHANG
;
Luping REN
;
Guangyao SONG
- Publication Type:Journal Article
- Keywords:
Activating transcription factor 4 (ATF4);
Lipid metabolism;
Glucose metabolism
- From:
Chinese Journal of Diabetes
2015;(9):856-858
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] Activating transcription factor 4 (ATF4) is an alkaline leucine zipper transcriptional factor ,which is involved in many physiological metabolism processes such as stress response ,inflammation and tumor growth. Moreover ,recent studies have shown that ATF4 also plays a key role in regulating lipid and glucose metabolism ,insulin secretion and insulin sensitivity ,which may related to pathways such as endoplasmic reticulum stress (ERS ) ,peroxisome proliferator‐activated receptor gamma coactivator (PGC1α) and target of rapamycin (TOR). This article summarized the recent research progress of ATF4 in regulating glucose and lipid metabolism.
