Clinical observation of double -way chemotherapy on brucea javanica oil emulsion combined with TP regi-men in treating malignant pleural effusion of NSCLC
10.3760/cma.j.issn.1008-6706.2015.18.026
- VernacularTitle:鸦胆子油乳联合 TP 方案双径路治疗恶性胸腔积液的临床观察
- Author:
Xiaoming HU
;
Wenbo LIAN
- Publication Type:Journal Article
- Keywords:
Pleural effusion,Malignant;
Carcinoma,Non -Small -Cell Lung;
Brucea javanica oil emulsion
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(18):2802-2805
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate short -term clinical efficacy and adverse effects of brucea javanica oil emulsion(BJOE)combined with TP regimen in treating malignant pleural effusion(MPE)of non -small cell lung cancer(NSCLC)by double -way chemotherapy.Methods Totally 91 patients with MPE of NSCLC diagnosed by pathology were builted into the central venous catheter.The patients were assigned to group A,B and C according to therapies.Group A(21 cases)accepted infusion of BJOE 60mL into thoracic cavity twice a week.Group B(33 cases) accepted TP regime therapy,which included paclitaxel(TAX)intravenous chemotherapy at a dose of 150mg/m2 and cisplatin(DDP)injecting into thoracic cavity at a dose of 60mg +0.9% sodium chloride injection 30mL in first day, the therapy was repeated every 3 weeks.Group C(38 cases)combined the therapies of group A′s and B′s.Clinical efficacy and adverse effects were evaluated after 6 weeks.Results The objective response rate(81.6%)for group C was higher than group A or B(χ2 =8.605,P <0.05),the same result were in CR ratio(55.3%)(χ2 =10.384,P <0.05)and PD ratio(5.3%)(χ2 =8.649,P <0.05).There were no serious adverse effects in the three groups.The occurring rate of white blood cell reduction in group A was lower than those of group B and C,there was statistically significance(χ2 =8.999,P <0.05).Conclusion The efficacy of BJOE combined with TP regimen in treating MPE of NSCLC by double -way chemotherapy is better than that of single chemotherapy or alone intrathoracic treatment, and the adverse effects could be well tolerated.
