Percutaneous kyphoplasty combined with zoledronic acid in the treatment of osteoporotic vertebral compres-sion fractures
10.3760/cma.j.issn.1008-6706.2015.18.028
- VernacularTitle:经皮椎体后凸成形术联合唑来膦酸治疗骨质疏松性胸腰椎压缩性骨折
- Author:
Wen SHEN
- Publication Type:Journal Article
- Keywords:
Osteoporotic Fractures;
Thoracic Vertebrae;
Lumbar Vertebrae;
Vertebroplasty;
Zoledronic Acid
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(18):2809-2813
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of osteoporotic vertebral compression fractures treated by percutaneous kyphoplasty combined zoledronic acid.Methods Patients admitted to our hospital′s depart-ment of orthopedics from February 2010 to December 2013 were reviewed,and 67 patients underwent percutaneous ky-phoplasty were admitted.According to the application of zoledronic acid or not,they were divided into 2 groups,with 39 cases and 28 cases,respectively.On 67 patients before surgery,3 days after surgery,the end of follow -up surgery, VAS,ODI,vertebral height average recovery rate and Cobb angle were compared.The BMD was also compared before and after surgery.Results There was no difference between the two groups in all above indices before treatment(t =0.308,P =0.758;t =0.476,P =0.635;t =0.397,P =0.693;t =0.342,P =0.733).3 days after surgery,the levels of VAS,ODI and Cobb angle all decreased(t =25.820,P <0.001 vs.t =24.988,P <0.001;t =16.801,P <0.001 vs.t =17.008,P <0.001;t =9.717,P <0.001 vs.t =7.525,P <0.001),while vertebral height average recovery rate were increased in both groups(t =8.300,P <0.001 vs.t =6.363,P <0.001 ),but there was no difference between the two groups(t =0.177,P =0.861;t =0.568,P =0.572;t =0.453,P =0.652;t =0.508,P =0.613).In the end of follow -up surgery,there was a significant difference between the two groups(t =4.779,P <0.001;t =7.041,P <0.001;t =2.517,P =0.014;t =2.406,P =0.019).There was no difference between the two groups in BMD(t =0.479,P >0.05),but it came to be a difference between the two groups in the end(t =2.710,P =0.009), although there was no difference in secondary fracture(23.1% vs.7.1%,χ2 =3.016,P =0.082).Conclusion Per-cutaneous kyphoplasty combined zoledronic acid has an excellent effect on osteoporotic vertebral compression frac-tures,it is worthy promoting.
