Adjuvant Therapy of Sepsis-associated Thrombocytopenia with Intravenous Immunoglobulin
10.3969/j.issn.1006-5725.2015.18.044
- VernacularTitle:静脉注射免疫球蛋白辅助治疗脓毒症相关性血小板减少症的疗效
- Author:
Mian PENG
;
Weiqiang FANG
;
Juyu CAI
;
Liyan LV
- Publication Type:Journal Article
- Keywords:
Sepsis associated thrombocytopenia;
Intravenous immunoglobulin
- From:
The Journal of Practical Medicine
2015;(18):3072-3074
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the adjuvant effect of intravenous immunoglobulin on patients with sepsis-associated thrombocytopenia. Methods A total of 229 patients with sepsis with platelet count less than 3 × 109/L, were included in this prospective, randomized, controlled study. The patients were divided into the intervening group and the control group. Conventional treatments were applied in the two both groups , while in the intervening group, intravenous immunoglobulin with a dose of 0.4 g/(kg·d) for 5 consecutive days was administered. The end-points were the platelet counts on day 1,day 3,day 5,and day 7 post-intravenous immunoglobulin, patients’ in-ICU time and the 28-day in-hospital mortality. Results Compared with the control group, the platelet count recovered dramatically after 5-day intravenous immunoglobulin in the intervening group. Moreover , the 28-day in-hospital mortality and in-ICU time were also dramatically improved in the intervening group. Conclusion Intravenous immunoglobulin can enhance the recovery of platelet counts , shorten the in-ICU time and reduce the hospital mortality in patients with sepsis- associated thrombocytopenia (PLT count < 30 × 109/L).
