The efficacy of atorvastatin and irbesartan in the treatment of early diabetic nephropathy and its influence on serum cystatin C and adiponectin
10.3760/cma.j.issn.1008-6706.2015.22.025
- VernacularTitle:阿托伐他汀联合厄贝沙坦治疗早期糖尿病肾病疗效观察及对血清胱抑素C和脂联素水平的影响
- Author:
Liqun WANG
;
Youjing WANG
;
Jiangyong LOU
- Publication Type:Journal Article
- Keywords:
Early diabetic nephropathy;
Atorvastatin;
Irbesartan;
Cystatin C;
Adiponectin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(22):3437-3439
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy of atorvastatin and irbesartan in the treatment of early diabetic nephropathy and the influence on serum cystatin C and adiponectin,thus to improve clinical outcomes.Methods 80 patients with early diabetic nephropathy met the inclusion criteria were randomly divided into observation group (40 cases)and control group(40 cases).All patients were given conventional diabetes comprehensive intervention, the control group then was given irbesartan 150mg/d,qd,the observation group was given atorvastatin on the basis of control group,20mg/d,qd,both two groups were treated for 12 weeks.The FBG,HbA1c,renal function indication (Scr,BUN,UAER),lipid parameters indication(TC,TG),cystatin C,adiponectin were detected.DBP,SBP were detected by 24h ambulatory blood pressure.Results The DBP,SBP,Scr,BUN,UAER,TC,TG,cystatin C,adiponec-tin of the observation group after treatment were lower than before treatment(P <0.05 or P <0.01).The BUN,TC, TG of the control group had no significant changes before and after treatment (P >0.05).The DBP,SBP,Scr,BUN, UAER,TC,TG,cystatin C,adiponectin of the observation group after treatment were lower than the control group (P <0.05 or P <0.01).Conclusion Atorvastatin combined with irbesartan can effectively control blood pressure, has overall improvement in glucose and lipid metabolism,effectively reduce adiponectin,inhibit glomerular dysfunc-tion,improve kidney function,it is a good method for prevention and treatment of early diabetic nephropathy.
