Effect of interferon gamma on immune factor and CD69 , CD107 a in patients with delayed type hypersensitivity
- VernacularTitle:γ-干扰素对迟发型药物变态反应患者免疫因子及CD69、CD107a影响研究
- Author:
Qingfeng WAN
;
Hua CAO
;
Wenbin ZHANG
- Publication Type:Journal Article
- Keywords:
gamma interferon;
delayed type hypersensitivity;
immune factor;
CD69;
CD107a
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;35(10):82-84
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of interferon gemma on immune factor and CD69, CD107a in patients with delayed type hypersensitivity by interferon gamma.Methods 76 cases with delayed type hypersensitivity were selected and divided into 2 groups.38 cases in control group were treated conventional therapy, 38 cases in experiment group were treated by interferon gamma.Peripheral blood CD69, CD107a, immune factor, T cell subsets and the treatment efficiency were compared after the treatment.Results Compared with the control group, the serum CD69 and CD107a levels were lower in the experimental group (P<0.05), serum IgG and IgA levels were higher, the serum IgE level was lower (P<0.05), and the CD3 +,CD4 +,CD4 +/CD8 +level was higher, serum CD8 + was lower (P<0.05) .The effective rate of the treatment group was significantly higher than that of the control group (P<0.05) .Conclusion Interferon gamma has good clinical effect in the patients with delayed type hypersensitivity, and can effectively reduce the levels of CD69 and CD107a in the peripheral blood, and regulate the immune function of the body.
