Effect of butylphthalide injection on serum neuron specific enolase, C-reactive protein and fatty acid binding protein levels in patients with cerebral vasospasm following aneurysmal subarachnoid hemorrhage
- VernacularTitle:丁苯酞注射液对动脉瘤性蛛网膜下腔出血脑血管痉挛患者血清神经特异性烯醇酶、C-反应蛋白及脂肪酸结合蛋白水平的影响
- Author:
Shufa ZHENG
;
Peisen YAO
;
Xiaofen HUANG
;
Lianghong YU
;
Wei WANG
;
Dezhi KANG
- Publication Type:Journal Article
- Keywords:
butylphthalide injection;
aneurysmal subarachnoid hemorrhage;
cerebral vasospasm;
neuron specific enolase;
C-reactive protein;
fatty acid binding protein
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;35(10):44-47
- CountryChina
- Language:Chinese
-
Abstract:
To investigate influence of butylphthalide injection on serum neuron specific enolase, C-reactive protein and fatty acid binding protein levels in patients with cerebral vasospasm following aneurysmal subarachnoid hemorrhage.Methods Ninety patients with cerebral vasospasm were admitted to The First Affiliated Hospital of Fujian Medical University, then the patients were divided into two groups: The control group (45 patients) was treated with nimodipine and triple-H therapy after surgery;in addition to nimodipine and triple-H therapy, butylphthalide injection was administered to the experimental group(45 patients).Transcranial doppler(TCD)was used for the evaluating cerebral artery blood flow velocity, and the serum neuron specific enolase(NSE), C-reactive protein(CRP) and fatty acid binding protein(FABP) levels in patients with cerebral vasospasm were measured. Results The experimental group improved significantly more than the control group, a significant decrease in cerebral blood flow velocity of the middle cerebral artery in the experimental group as measured by TCD (P<0.05).The serum levels of NSE, CRP and FABP in the patients in the experimental group decreased more significantly (P<0.05).And the incidence of cerebral infarction in experimental group was lower than that in control group (P<0.05).Conclusion The serum levels of NSE, CRP and FABP in the patients with cerebral vasospasm following aneurysmal subarachnoid hemorrhage could be significantly reduced by administration of butylphthalide injection, which also could improve cerebral blood supply.Therefore, administration of butylphthalide injection is an effective treatment for cerebral vasospasm.
