Effect of laparoscope anesthesia inducted by sevoflurane combined with different doses of propofol on VEGF-C and PGE2 in patients with hysteromyoma
- VernacularTitle:七氟烷分别联合不同剂量异丙酚对腹腔镜子宫肌瘤患者术后血清VEGF-C与PGE2影响研究
- Author:
Guohua LIU
;
Tianquan WEI
;
Baolin ZHONG
- Publication Type:Journal Article
- Keywords:
sevoflurane;
propofol;
laparoscopic uterine fibroids;
vascular endothelial growth factor-C;
prostaglandin E2
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;35(10):70-72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of laparoscope anesthesia inducted by sevoflurane combined with different doses of propofol on vascular endothelial growth factor-C (VEGF-C) and prostaglandin E2(PGE2)in patients with hysteromyoma.Methods 77 cases of patients with uterine fibroids were selected and divided into two groups.40 cases in group A were anesthetized inducted by 2.0 mg/kg propofol combined with sevoflurane, 37cases in group A were anesthesia inducted by 1.0 mg/kg propofol combined with sevoflurane.VEGF-C and PGE2 in serum were compared before and 48h after the operation.Results Compared with preoperation, VEGF-C and PGE2in serum were lower (P<0.05), VAS score was lower (P<0.05);Compared with group B, VEGF-C and PGE2 in serum of the group A were lower (P<0.05), VAS score was higher (P<0.05).Conclusion Different doses of propofol on serum VEGF-C and PGE2 in patients with laparoscopic uterine fibroids have different effects, 1.0 mg/kg has a sedative effect, 2 0 mg/kg with anesthesia induction.
