Effect of TPF induction chemotherapy on locally advanced squamous-cell cancer of hypopharynx
10.16066/j.1672-7002.2015.11.007
- VernacularTitle:局部晚期喉咽鳞状细胞癌紫杉醇+顺铂+氟尿嘧啶方案诱导化疗的近期疗效观察
- Author:
Bing ZHANG
;
Jugao FANG
;
Shurong ZHANG
;
Xiaohong CHEN
;
Yigeng HOU
;
Pingdong LI
;
Qi ZHONG
;
Lizhen HOU
- Publication Type:Journal Article
- Keywords:
Carcinoma,Squamous Cell;
Antineoplastic Combined Chemotherapy Protocols;
Cisplatin;
Fuorouracil;
Treatment Outcome;
paclitaxel
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2015;(11):566-568
- CountryChina
- Language:Chinese
-
Abstract:
[ABSTRACT]OBJECTIVETo observe the short term effects and adverse effects of induction chemotherapy with Paclitaxel,Cisplatin and Fluorouracil(TPF) in locally advanced squamous cell cancer of hypopharynx. METHODS78 cases locally advanced squamous-cell cancer of hypopharynx form jan 2011 to oct 2013 for the first time treated by TPF scheme,after 2 cycles,to recheck CT scan and evaluate therapeutic effective.RESULTSAll 78 cases patients achieved 156 cycles chemotherapy,CR was 4 cases (5.1%),PR 55 cases (70.5%),SD 17 cases (21.8%), PD 2 cases (2.6%). Total effective rate (CR+PR) was 75.6%,and with low incidence ofⅢ/Ⅳ grade side effect. Logistic regression analysis shows that there is a significant correlation between effective rate and low differentiation cancer.CONCLUSIONFor locally advanced squamous-cell cancer of hypopharynx patients,the TPF chemotherapy scheme showed good therapeutic effective and safety,could be a choice for the induction chemotherapy treatment in locally advanced squamouscell cancer of hypopharynx. The patients with low differentiation cancer may have benefit from the induction chemotherapy.
