Relationship between Helicobacter pylori Infection and Expression of FOXA1 in Gastric Mucosa

VernacularTitle:幽门螺杆菌感染与胃黏膜中FOXA1表达的相关性
Author: Xiaojun LOU ; Jie CHEN ; Jun LIU ; Fei YAO
Publication Type:Journal Article
Keywords: Helicobacter pylori; FOXA1; Stomach Diseases; Immunohistochemistry
From: Chinese Journal of Gastroenterology 2015;(11):680-682
CountryChina
Language:Chinese
Abstract: Background:Helicobacter pylori( Hp)is listed as Group 1 human carcinogen. Transcription factor FOX family plays important role in the development of tumor,and FOXA1 is a key target transcription factor of some microRNAs( miRNAs). Aims:To investigate the relationship of Hp infection with expression of FOXA1 in gastric mucosal tissues. Methods:Eighty patients undergone gastroscopy from Jan. 2014 Sept. 2014 were enrolled. Hp infection was detected by 14 C-urease breath test( 14 C-UBT),modified Giemsa staining and bacterial culture. Expression of FOXA1 in gastric mucosal tissues was determined by immunohistochemical SP method. Results:FOXA1 expression in Hp positive tissues was significantly higher than that in Hp negative tissues(73. 8% vs. 47. 4%;χ2 =4. 81,P<0. 05). Conclusions:High expression of FOXA1 in gastric mucosal tissues suggests that miRNAs pathway may be one of the molecular mechanisms of Hp infection leading to gastric intraepithelial neoplasia even gastric cancer.