Effect of glutamine on serum CEA, AFP and T cell immune function in postoperative patients with gastric cancer
- VernacularTitle:谷氨酰胺对胃癌术后患者血清CEA、AFP及T细胞免疫功能的影响
- Author:
Anan GONG
;
Ke MIAO
- Publication Type:Journal Article
- Keywords:
glutamine;
gastric cancer;
postoperative;
nutritional parameters;
carcino embryonie antigen;
alpha fetal protein;
immune function
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;35(10):90-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of glutamine on the serum carcino embryonie antigen (CEA) , alpha fetal protein (AFP) and T cell immune function in postoperative patients with gastric cancer.Methods 52 postoperative patients with gastric cancer from Yiwu Central Hospital were selected and randomly divided into control group and experimenal group, 26 cases in each group.The control group received routine nutritional therapy, and experimental group received alanyl -glutamine injection on the basis of control group.The serum nutritional parameters, CEA, AFP, CD4 +T, CD8 +T levels were compared post-treatment.Results Compared with control group post-treatment, the serum albumin (ALB) and pre-albumin (PA) levels were higher (P<0.05), the CEA and AFP levels were lower (P<0.05),the serum levels of CD4 +T and CD4 +T/CD8 +T were higher (P<0.05),CD8 +T level were lower (P<0.05).Conclusion Glutamine could significantly improve the clinical symptoms of patients with gastric cancer after surgery,and it is speculated that the mechanism may be the increase of serum ALB, PA levels, the decrease of CEA, AFP levels and the improvement of immune function.
