Effect of folic acid combined with xin funing on CRP,HGF, IL-2,TNF-α of patients with cervical cancer caused by human papillomavirus
- VernacularTitle:叶酸联合辛复宁对人乳头瘤病毒感染宫颈癌患者血清CRP、HGF、IL-2、TNF-α水平影响研究
- Author:
Ligang JIA
;
Yuan ZHANG
;
Fei TIAN
- Publication Type:Journal Article
- Keywords:
folic acid;
Xin Funing;
cervical cancer;
C reactive protein;
hepatocyte growth factor;
interleukin-2;
tumor necrosis factor-α
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;35(10):96-98
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of folic acid combined with xin funing on CRP, HGF, IL-2,TNF-αof patients with cervical cancer caused by human papillomavirus.Methods 80 cases of cervical cancer patients were randomly divided into control group, 40 cases in the control group were given conventional chemotherapy, 40 cases in the experimental group were on the base of the control with folic acid combined with xin funing.CRP, HGF, TNF-α, IL-2 and T lymphocyte subsets were compared before and after the treatment.Results Compared with the control group, the serum CRP, HGF and TNF-αof the experiment group were lower(P<0.05), IL-2 levels was higher (P<0.05), CD4 +and CD4 +/CD8 +level were higher(P<0.05), level of CD8 +was lower(P<0.05) and the clinical effective rate were higher(P<0.05).Conclusion Folic acid combined with Xin Funing has important significance for the treatment of patients with cervical cancer.It is speculated that the mechanism may be to reduce the level of serum CRP and HGF in patients with cervical cancer, and to increase the level of IL-2, and to regulate immune cells.
