Progress on hyaluronic acid in treatment of osteoarthritis
- VernacularTitle:透明质酸治疗骨关节炎的研究进展
- Author:
Hong TIAN
;
Guihua HUANG
;
Mingjin DOU
- Publication Type:Journal Article
- Keywords:
hyaluronic acid;
osterarthritis;
mechanism;
application
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;35(10):168-171
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis is a common chronic degenerative disease, which is currently the main drug therapy.Hyaluronic acid (HA) is a kind of glycosaminoglycan in the interstitial cells, which has the character of viscoelasticity, lubricity, biocompatibility,biodegradability and anti-inflammatory. It is wide applicated in the treatment of osteoarthritis.However, the half-life of the common hyaluronic acid injected into the joint cavity is shorter, patients need frequent dosing and the compliance is poor, research on new uses of hyaluronic acid formulations and clinical pharmacy workers is the new direction of research.In this paper, the recent advance of HA on function, safety, effectivity and novel application in osteoarthritis therapy are summarized.
