Correlation among cardiac function,inflammation factor and plasma testosterone level in aged male patients with chronic heart failure
10.3969/j.issn.1008-0074.2015.06.10
- VernacularTitle:老年男性慢性心衰患者血浆睾酮与心功能和炎症的相关性
- Author:
Wen YIN
;
Haiyan LIU
;
Haoyu WANG
;
Tao LIU
;
Shirong CHEN
- Publication Type:Journal Article
- Keywords:
Testosterone;
Heart failure;
Inflammation
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(6):620-622
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the correlation among cardiac function ,inflammation factor and plasma testoster‐one level in aged male patients with chronic heart failure (CHF) .Methods :A total of 91 male CHF inpatients were selected from our hospital ,including 31 cases with NYHA cardiac function class Ⅱ ,30 cases with class Ⅲ and 30 ca‐ses with class Ⅳ .Another 40 corresponding male patients without CHF were regarded as non‐CHF control group . Plasma levels of testosterone ,interleukin (IL)‐6 ,tumor necrosis factor (TNF)–α and brain natriuretic peptide (BNP) and cardiac function were compared between two groups .Results:Compared with non‐CHF control group , there were significant reductions in plasma testosterone level , P<0. 05 or 0. 01 ,and they more reduced along with NYHA cardiac function class rose in all CHF subgroups ,P<0.05 or <0.01 .Correlation analysis indicated that tes‐tosterone level was inversely correlated with IL‐6 and TNF‐α levels (r= -0.244 , -0.322 , P<0.05 both) ,and positively correlated with LVEF (r=0.322 ,P=0.01) .Conclusion:In patients with chronic heart failure ,the poo‐rer cardiac function is ,the lower plasma testosterone level is .Testosterone level measurement contributes to judging disease degree and prognosis of patients with chronic heart failure .
