Prevention and Treatment of Portal Hypertension Complicated with Hemorrhage in Patients with Liver Cirrhosis through New Knowledge on its Pathogenesis
10.3969/j.issn.1008-7125.2015.11.001
- VernacularTitle:掌握发病新机制，有效防治肝硬化门静脉高压出血
- Author:
Hai LI
- Publication Type:Journal Article
- Keywords:
Liver Cirrhosis;
Portal Hypertension;
Hemorrhage;
Viscera;
Hemodynamics
- From:
Chinese Journal of Gastroenterology
2015;(11):641-643
- CountryChina
- Language:Chinese
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Abstract:
The mortality rate of portal hypertension complicated with variceal bleeding in decompensated liver cirrhosis patients decreased dramatically in recent three decades,mainly benefited from the“forward blood flow”hypothesis proposed in the 1980s and splanchnic vascular tone theory to explain the mechanism of portal hypertension in advanced liver cirrhosis,thereby introducing clinically three types of drugs,namely,somatostatin and its derivatives,terlipressin,and nonselective beta blockers. The abovementioned drugs together with endoscopic variceal ligation, sclerotherapy and histoacryl injection have made a milestone contribution to the dramatic decreasing of mortality rate in liver cirrhosis patients with portal hypertension and bleeding. Recent advances in knowledge on the molecular mechanisms of increase of hepatic portal blood inflow,hepatic sinusoidal endothelium dysfunction and neovascularization form the basis of current emerging therapies for portal hypertension. We can expect that most likely this will result in more effective treatment and prevention for portal hypertension in liver cirrhosis patients.
