Correlation of NADPH oxidase subunit p22phox gene C242T polymorphism with left ventricular hypertrophy in Chinese Korean hypertensive patients
10.3969/j.issn.1006-5725.2015.18.006
- VernacularTitle:NADPH氧化酶p22phox亚基C242T基因多态性与中国朝鲜族高血压患者左心室肥厚的相关性
- Author:
Jinglan CUI
;
Lianshan PIAO
;
Guangming JIN
- Publication Type:Journal Article
- Keywords:
Hypertension;
NADPH oxidase subunit p22phox gene;
Korean nationality;
Polymorphism;
Left ventricular hypertrophy
- From:
The Journal of Practical Medicine
2015;(18):2957-2959
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation between the NOSP gene C242T polymorphism and Chinese Korean nationality EH patients with LVH. Methods 108 Chinese Korean controls and 231 Chinese Korean EH patients were enrolled in the research.NOSP gene C242T polymorphism was analyzed by PCR. EH patients were divided into EH and EH+LVH group,all of them were evaluated with CDUS for left ventricular mass index. Results The distribution of NOSP gene C242T polymorphism showed no significant difference compared with controls and EH group.There was significant difference in distribution of CC vs CT+TT genotype between EH and EH+ LVH patients.CC genotype is more dangerous for EH patients combined with LVH than CT and TT genotypes. Conclusions The NOSP gene C242T polymorphism has no relation with EH in Korean nationality people. The NOSP gene C242T polymorphism has relation with EH+LVH; and the CC genotype is a susceptible gene for the Korean EH patients with LVH.
