Association of CYP1A1 gene polymorphism with adverse reactions of high-does methotrexate in children with acute lymphocytic leukemia
10.3969/j.issn.1006-5725.2015.18.007
- VernacularTitle:CYP1A1基因多态性与急性淋巴细胞白血病儿童大剂量甲氨蝶呤毒副反应的关系
- Author:
Zeqiao ZOU
;
Lijie YUE
;
Yanfei REN
- Publication Type:Journal Article
- Keywords:
CYP1A1;
Polymorphism;
Methotrexate;
Acute lymphocytic leukumia
- From:
The Journal of Practical Medicine
2015;(18):2960-2962
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between CYP1A1 gene polymorphism and toxicities related to high-does methotrexate of childhood acute leukemia. Methods The SNPs were detected by reverse transcriptional (RT)-PCR-denaturing gradient gel elelctrphoresis combined with direct sequencing in 51 children with acute leukemia. Toxicities were collected thereby. Results Only one SNP,A4889G, was screened in CYP1A1. A4889G polymorphism was not associated with all the toxicities (P > 0.05). High-risk ALL children were more likely to increase the risk of thrombocytopenia compared with standard-risk ALL (P< 0.05). Conclusions CYP1A1 A4889G polymorphism may be not association with all toxicities after HD-MTX ,but the thrombocytopenia may be relevant to the risk degree of ALL children.
