The effect of Danhong injection on hemodynamic parameters, Cys-c, and Hcy in patients with transient cerebral ischemia
10.3760/cma.j.issn.1673-4246.2015.11.006
- VernacularTitle:丹红注射液对短暂性脑缺血发作患者血流动力学及血清胱抑素 C和同型半胱氨酸的影响
- Author:
Lixin YE
;
Xiaotao ZHONG
;
Na LONG
;
Suping LAI
- Publication Type:Journal Article
- Keywords:
Ischemic attack,Transient;
Danhong injection;
Hemodynamics;
Cystatin C;
Homocysteine;
Integrated Chinese traditional and Western medicine therapy
- From:
International Journal of Traditional Chinese Medicine
2015;(11):984-986
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the effect of Danhong injection on cerebral vascular hemodynamic parameters, Cys-c and Hcy in patients with transient cerebral ischemia(TIA), and analyze its clinical effect. Methods 80 TIA patients were selected. The patients were divided into a control group and a Danhong injection observation group with 40 cases each group. The control group was given conventional treatment, and the observation group was given conventional treatment and Danhong injection. The treatment course was 14 d. The hemodynamic parameters, Cys-c and Hcy expresssion were observed. Clinical effect was analyzed. Results After treatment, average blood flow speed (20.07 ± 4.28 cm/s vs. 16.17 ± 2.46 cm/s, t=5.230), average blood flow (11.14 ± 2.24 ml/s vs. 9.54 ± 1.65 ml/s, t=3.637), and cerebral vascular resistance (1 602.4 ± 98.3 kPa/s·m-1 vs. 1 738.5 ± 104.3 kPa/s·m-1, t=6.024) was significantly improved in the observation group than those in the control group (P<0.05). Cys-c (0.48 ± 0.11 mg/L vs. 0.71 ± 0.14 mg/L, t=8.170) and Hcy (17.45 ± 3.26 μmol/L vs. 23.62 ± 4.12 μmol/L, t=7.428) were significantly decreased in the observation group than those in the control group (P<0.05). The recurrence rate of TIA and cerebral infarction were 7.5% and 5% in observation group, which were significantly lower than that of 22.5% and 15% in control group (χ2=2.451, P<0.05;χ2=2.630, P<0.05).Conclusion Danhong injection can reduce the expression of Cys-c and Hcy and recurrence rate of TIA and cerebral infarction.
