Clinical Study on External Bath of Modified Huangqi Guizhi Wuwu Decoction for Peripheral Neurotoxicity Induced by Oxaliplatin

VernacularTitle:加味黄芪桂枝五物汤外洗治疗奥沙利铂致周围神经病变临床研究
Author: Jie SHEN ; Shengli HE ; Xianjun SUN ; Nanhua HU ; Yunyun CAI
Publication Type:Journal Article
Keywords: oxaliplatin; peripheral neurotoxicity; Huangqi Guizhi Wuwu Decoction
From: Chinese Journal of Information on Traditional Chinese Medicine 2015;22(11):13-15
CountryChina
Language:Chinese
Abstract: Objective To observe clinical efficacy of external bath of modified Huangqi Guizhi Wuwu Decoction in relieving peripheral neurotoxicity induced by oxaliplatin.Methods Sixty patients were randomly divided into control group and treatment group (30 cases in each group). Both groups received intramuscular injection of mecobalamine (0.5 mg/d, three times a week). At the same time, the treatment group received external bath of modifiedHuangqi Guizhi Wuwu Decoction. All the courses of treatment lasted for 14 days. Clinical efficacy and adverse reactions of the two groups were observed.Results The total effective rate of treatment group was 73.3% (22/30), which was superior to that of 40.0% (12/30) in the control group, with statistical significance (P<0.05), without any adverse reaction.Conclusion External bath of modifiedHuangqi Guizhi Wuwu Decoction is effective as supportive care for alleviating chronic peripheral neurotoxicity induced by oxaliplatin.