Pathogenic features and risk factors of invasive fungal infection in patients with hematopathy
10.3969/j.issn.1671-9638.2015.10.006
- VernacularTitle:血液病合并侵袭性真菌感染病原学及危险因素
- Author:
Fan WANG
;
Zhihai HAN
;
Jiguang MENG
;
Yongqun LI
;
Wei CHEN
;
Chunting ZHAO
- Publication Type:Journal Article
- Keywords:
hematopathy;
infection;
pathogen;
invasive fungal infection;
drug resistance,microbial;
risk factor
- From:
Chinese Journal of Infection Control
2015;(10):672-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the status of invasive fungal infection(IFI)associated with hematopathy,and evaluate drug resistance and risk factors of fungal infection.Methods 1 246 cases of infection occurred in patients in a hospital from 2006 to 2010 were analyzed retrospectively,pathogenic features and risk factors of IFI were ana-lyzed.Results There were 281 cases of fungal infection,and 162 fungal isolates were isolated,the main infection site was respiratory tract(134 isolates,82.72%).Four major Candida were Candida albicans ,Candida tropicalis , Candida glabrata ,and Candida krusei ;in 2006-2009,the main fungi were Candida albicans ,while in 2010,the majority were non-Candida albicans .The resistant rates of four isolated Candida to fluconazole and itraconazole were 5.15% and 4.41 % respectively,6 isolated Candida krusei strains were all resistant to both fluconazole and itraconazole,voriconazole-resistant strain was not found.The independent risk factors for fungal infection were dia-betes and duration time of agranulocytosis>14 days.Conclusion The proportion of infection caused by non-Candi-da albicans increased obviously,fluconazole-and itraconazole-resistant non-Candida albicans strains have emerged, comprehensive measures should be adopted to prevent IFI actively and treat patients early.
