Study on Quality Standards for Compound Shatagan Oral Liquid
10.3969/j.issn.1005-5304.2015.11.024
- VernacularTitle:复方沙塔干口服液质量标准研究
- Author:
Shuangying YU
;
Xiuhua LIU
;
Feng ZHANG
;
Shujuan PIAO
;
Wenquan LU
- Publication Type:Journal Article
- Keywords:
compound Shatagan Oral Liquid;
ferulic acid;
HPLC;
TLC;
quality standard
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;22(11):86-88
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the quality standards for compound Shatagan Oral Liquid. Methods Chuanxiong Rhizoma was identified by TLC. The content of ferulic acid was determined by HPLC. Separation was performed on a Diamonsil C18 column (4.6 mm × 250 mm, 5μm) with a mobile phase consisting of methanol-1% acetic acid solution in gradient elution (0-5 min, 35% methanol;5-8 min, 35%→23% methanol;8-22 min, 23% methanol) at 30℃;The flow rate was 1.0 mL/min;The injection volume was 5μL;The detection wavelength was 322 nm.Results Ferulic acid showed a good linear relationship in the range of 0.039 4-0.630 0μg (r=0.999 7,n=7). The average recovery was 98.22% and RSD was 2.62% (n=6).Conclusion The method is reliable, sensitive and with repeatability, which can be used as the quality control method for compound Shatagan Oral Liquid.
