Effects of endometriosis on the reproductive ability of mice
10.3969/j.issn.1005-4847.2015.05.007
- VernacularTitle:子宫内膜异位症对小鼠生育能力的影响
- Author:
Yangyang CUI
;
Weiwei SUN
;
Ruihua ZHAO
;
Cai XU
;
Tiansi WU
- Publication Type:Journal Article
- Keywords:
Endometriosis;
Mouse;
Reproductive ability
- From:
Acta Laboratorium Animalis Scientia Sinica
2015;23(5):479-483
- CountryChina
- Language:Chinese
-
Abstract:
Objectives The aim of the study was to establish a mouse model of endometriosis , and to observe the effects of endometriosis on the reproductive ability in the mice .Methods The mouse models of endometriosis was estab-lished by subcutaneous and intraperitoneal injection of heterogenous endometrium .The pregnancy rate and live embryo number in the experimental , sham operation and blank groups were observed and compared , and the effects of endometrio-sis on reproductive ability of the mice were evaluated .Results Two weeks after the establishment of the mouse model of endometriosis , there were lesions in the peritoneal cavity and subcutaneous tissue of the mice .Compared the pregnancy rates among the model group , sham operation group and blank group , the differences were statistically significant ( P<0.05).Compared the live embryo number in the three groups , there were also significant differences (P<0.05).Con-clusions A mouse model of endometriosis is successfully established , and it demonstrates that endometriosis may affect the reproductive ability of mice .
