Research progress on the development and functions of tissue barriers using zebrafish model
10.3969/j.issn.1005-4847.2015.05.016
- VernacularTitle:模式动物斑马鱼在组织屏障发育及功能研究中的进展
- Author:
Qiang LI
;
Jingjing ZHANG
- Publication Type:Journal Article
- Keywords:
Zebrafish;
Tissue barrier;
Blood-brain barrier;
Development;
Pathogenesis
- From:
Acta Laboratorium Animalis Scientia Sinica
2015;23(5):523-528
- CountryChina
- Language:Chinese
-
Abstract:
Zebrafish has been widely used as an important model system in research fields of genetic and develop -mental biology over the past 20 years.Similar to the mammalians and other vertebrate animals , zebrafish also has various tissue barriers.In recent years, more and more important progress of tissue barrier studies have been achieved using ze -brafish as in vivo model, such as blood-brain barrier.These findings contribute to the understanding of the mechanisms of diseases caused by the disorders of physiological barriers .It also helps with the modulation of the permeability of tissue bar-riers for drug delivery .This review summaries recent progress of zebrafish applications in the study of tissue barriers , such as blood-brain barrier, blood-retina barrier, epidermal barrier, etc.
