Prediction of breast cancer and prognosis by 21-gene oncotype Dx
10.3760/cma.j.issn.1674-6090.2015.05.007
- VernacularTitle:21基因检测对乳腺癌预测和预后的研究
- Author:
Kai LU
;
Yanwen LIU
;
Hui LI
;
Dong LIU
;
Hongling YE
;
Liang XU
;
Su LIU
- Publication Type:Journal Article
- Keywords:
Breast cancer;
21-gene Oncotype Dx;
Q-PCR;
Prognosis
- From:
Chinese Journal of Endocrine Surgery
2015;(5):376-380
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the prognostic and predictive significance of 21-gene assay ( oncotype DX)in breast cancer.Methods Real-time quantitative PCR(RT-QPCR)was used to detect 21 gene expression in breast cancer tissues (100 cases)and recurrence score(RS)was calculated.Results Among the 100 cases, 52 cases had low RS , 22 cases had middle RS , and 26 cases had high RS .The recurrence rate of five years was 1.92%,4.55%and 15.38%respectively.21 gene expression had nothing to do with patients'age, tumor size, histological grade , lymph node metastasis state , ER expression , or PR expression .It was associated with HER 2 expression .Conclusions 21 genes is a good prediction factor in breast cancer and its prognosis .
